AUTHOR=Fang Jinzhi , Zhang Yuzhong , Li Ruifeng , Liang Lanlan , Yu Juan , Hu Ziqi , Zhou Lingling , Liu Renwei TITLE=The utility of diffusion-weighted imaging for differentiation of phyllodes tumor from fibroadenoma and breast cancer JOURNAL=Frontiers in Oncology VOLUME=13 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.938189 DOI=10.3389/fonc.2023.938189 ISSN=2234-943X ABSTRACT=Objective

To evaluate the utility of apparent diffusion coefficient (ADC) values for differentiating breast tumors.

Methods

The medical records of 17 patients with phyllodes tumor [PT; circular regions of interest (ROI-cs) n = 171], 74 patients with fibroadenomas (FAs; ROI-cs, n = 94), and 57 patients with breast cancers (BCs; ROI-cs, n = 104) confirmed by surgical pathology were retrospectively reviewed.

Results

There were significant differences between PTs, FAs, and BCs in ADCmean, ADCmax, and ADCmin values. The cutoff ADCmean for differentiating PTs from FAs was 1.435 × 10−3 mm2/s, PTs from BCs was 1.100 × 10−3 mm2/s, and FAs from BCs was 0.925 × 10−3 mm2/s. There were significant differences between benign PTs, borderline PTs, and malignant PTs in ADCmean, ADCmax, and ADCmin values. The cutoff ADCmean for differentiating benign PTs from borderline PTs was 1.215 × 10−3 mm2/s, and borderline PTs from malignant PTs was 1.665 × 10−3 mm2/s.

Conclusion

DWI provides quantitative information that can help distinguish breast tumors.