AUTHOR=Liu Zhao , Zhao Xiaowen , Wang Ruihong , Tang Xiangyue , Zhao Yuxiang , Zhong Guanghui , Peng Xin , Zhang Chunlin 

TITLE=Heterogeneous pattern of gene expression driven by TTN mutation is involved in the construction of a prognosis model of lung squamous cell carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.916568

DOI=10.3389/fonc.2023.916568

ISSN=2234-943X

ABSTRACT=<sec><title>Objective</title><p>To investigate the impact that <italic>TTN</italic> mutation had on the gene heterogeneity expression and prognosis in patients with lung adenocarcinoma.</p></sec><sec><title>Methods</title><p>In this study, the Cancer Genome Atlas (TCGA) dataset was used to analyze the <italic>TTN</italic> mutations in lung adenocarcinoma. Lung adenocarcinoma data was collected from the TCGA database, clinical information of patients was analyzed, and bioinformatics statistical methods were applied for mutation analysis and prognosis survival analysis. The results were verified using the GEO dataset.</p></sec><sec><title>Results</title><p>The incidence of <italic>TTN</italic> mutations in lung adenocarcinoma was found to be 73%, and it was related to the prognosis of lung adenocarcinoma. Ten genes were screened with significant contributions to prognosis. A prognosis model was constructed and verified by LASSO COX analysis in the TCGA and GEO datasets based on these ten beneficial factors. The independent prognostic factor H2BC9 for <italic>TTN</italic> mutation-driven gene heterogeneity expression was screened through multi-factor COX regression analysis.</p></sec><sec><title>Conclusion</title><p>Our data showed that the gene heterogeneity expression, which was driven by <italic>TTN</italic> mutations, prolonged the survival of lung adenocarcinoma patients and provided valuable clues for the prognosis of <italic>TTN</italic> gene mutations in lung adenocarcinoma.</p></sec>