AUTHOR=Su Chen , Zhu Xiaobo , Zhang Junjie TITLE=Primary mediastinal Ewing’s sarcoma presenting with sudden and severe chest pain: a case report JOURNAL=Frontiers in Oncology VOLUME=13 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1290603 DOI=10.3389/fonc.2023.1290603 ISSN=2234-943X ABSTRACT=

Ewing’s sarcoma, characterized by small round cell morphology, is a rare malignancy, with mediastinal Ewing’s sarcoma being even less common. This case describes a distinctive presentation of primary mediastinal Ewing’s sarcoma in a 32-year-old male presenting with sudden and severe chest pain. Initial evaluation excluded cardiac and pulmonary emergencies, revealing a posterior mediastinal mass through advanced imaging. The patient’s clinical symptoms significantly improved following the complete resection of the tumor via thoracoscopy. Subsequent analysis incorporating imaging, histological, immunohistochemical and genetic findings led to the conclusive diagnosis of primary mediastinal Ewing’s sarcoma.