AUTHOR=Liu Xue-Fei , Ju Shuai , Wang Ke-Ying , Li Ying , Qiang Jin-Wei 

TITLE=The prevalence rate, mortality, and 5-year overall survival of Schistosoma japonicum patients with human malignancy

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1288197

DOI=10.3389/fonc.2023.1288197

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Only a few studies have focused on the association between <italic>Schistosoma japonicum</italic> and human malignancy. The aim of this study was to update the prevalence rate, mortality, and 5-year overall survival of <italic>S. japonicum</italic> patients with human malignancy.</p></sec><sec><title>Methods</title><p>From January 20, 2018, to January 31, 2021, 5,866 inpatients were included in the study. A total of 656 <italic>S. japonicum</italic> patients with malignancy were identified. Cases were stratified by gender and age groups. The cancer sites, prevalence rate, mortality, and 5-year overall survival of the patients were reported. The <italic>S. japonicum</italic> patients with malignancy were further divided into a non-digestive system tumor group (n = 309) and a digestive system tumor group (n = 347), including those with cancer in the esophagus, stomach, colon, rectum, liver, gallbladder, bile duct, or pancreas. Chi-squared test and odds ratio with confidence intervals were performed between these two groups.</p></sec><sec><title>Results</title><p>Lung cancer was found the most common malignancy, accounting for 18.6% of all malignancies, followed by colorectal, stomach, liver, and gallbladder cancers. These five leading malignancies accounted for approximately 61.8% of all cases. Colorectal cancer was the leading cause of malignancy death, followed by lung, stomach, gallbladder, and liver cancers. These five leading causes of death accounted for approximately 55.6% of all death cases. Statistical significance was found in the prevalence rate between <italic>S. japonicum</italic> and non-<italic>S. japonicum</italic> patients with/without digestive system tumor (p &lt; 0.001). The odds ratio of <italic>S. japonicum</italic> patients with digestive system tumors was 1.6 (95%CI: 1.4–1.9).</p></sec><sec><title>Conclusion</title><p><italic>S. japonicum</italic> contributes to a significant prevalence and mortality in digestive system tumors, including colorectal, stomach, liver, and gallbladder cancers.</p></sec>