AUTHOR=Chen Qian , Zheng Kai , Xu Ming , Yan Ning , Hai Gong , Yu Xiuchun 

TITLE=Anlotinib combined with radiotherapy and chemotherapy for recurrent pelvic osteosarcoma treatment: a case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1283932

DOI=10.3389/fonc.2023.1283932

ISSN=2234-943X

ABSTRACT=At present, the treatment of recurrent pelvic osteosarcoma is too simple, and most of them are treated with chemotherapy, radiotherapy and/or combined surgery. Here, we report a 29-year-old man diagnosed with local recurrent pelvic osteosarcoma. Imaging showed that the tumor had obvious enhancement and abundant blood vessels. There was no indication for surgery. After the patient , s consent was obtained, we used anlotinib as a sequential treatment to chemotherapy. During the first course of adjuvant chemotherapy, the patient was treated with intensity-modulated radiotherapy (IMRT) with a total dose of 60 Gray equivalents. No disease recurrence was reported at 25 months after multimodal combination therapy.