AUTHOR=Zhang Xin , Zhang Xinran , Geng Dandan , Zhao Chenguang , Wang Yingnan , Fan Yao , Gao Shasha , Wei Jinmei , Zhang Fengbin 

TITLE=Targeted therapy for multiple gene mutations in multiple metastases of advanced gastric cancer: a case report

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1257011

DOI=10.3389/fonc.2023.1257011

ISSN=2234-943X

ABSTRACT=<p>In China, gastric cancer is the second most common cause of cancer-related death, after lung cancer. At present, the morbidity and mortality rates of gastric cancer are increasing, and targeted therapy for gastric cancer has become a research hotspot. Herein, we report a patient with multiple metastases from advanced gastric cancer. After identifying <italic>MET</italic> gene amplification, initial treatment induced regression of the tumor. However, in later stages, due to the overexpression or mutation of <italic>HER-2</italic>, <italic>KRAS</italic>, <italic>TP53</italic>, and other genes, the targeted drug therapy became ineffective, and the disease progressed rapidly, leading to the death of the patient.</p>