AUTHOR=Wang Lu , Wang Qian , Xu Zhen , Yang Linli , Wang Wuliang 

TITLE=The efficacy and safety of 5-fluorouracil/cisplatin/vincristine as a multi-agent chemotherapy regimen in gestational trophoblastic neoplasia

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1240972

DOI=10.3389/fonc.2023.1240972

ISSN=2234-943X

ABSTRACT=<sec><title>Objective</title><p>To determine the efficacy and safety of the 5-fluorouracil (5-FU), cisplatin, and vincristine (FPV) chemotherapy regimen in patients with gestational trophoblastic neoplasia (GTN).</p></sec><sec><title>Methods</title><p>We performed a retrospective study of 96 GTN patients with International Federation of Gynecology and Obstetrics (FIGO) scores of 5 or greater in the Second Affiliated Hospital of Zhengzhou University from October 2013 to October 2019, including 54 patients who received FPV chemotherapy and 42 who received 5-FU/actinomycin D/vincristine (FAV) chemotherapy. A pulsed intravenous device was used to administer 5-FU. The clinical characteristics, adverse events, and response rates were compared between the groups.</p></sec><sec><title>Results</title><p>The patients in the FPV and FAV groups received a total of 228 and 190 courses of chemotherapy, respectively. Complete response (CR) was found in 88.89% (48/54) and 90.48% (38/42) of patients in the FPV group and FAV group, respectively (<italic>p</italic> = 0.801). Both chemotherapy regimens yielded CR in all low-risk patients (100% vs. 100%), whereas 86.67% and 88.24% of high-risk patients achieved CR (FPV vs. FAV, <italic>p</italic> = 0.836), respectively. The most common adverse events (AEs) were myelosuppression and gastrointestinal reactions including neutropenia (83.97%), anemia (60.05%), and nausea (46.41%). In comparison to those in the FAV group, patients in the FPV group reported higher rates of grade 1/2 nausea (53.51% vs. 37.89%, <italic>p</italic> = 0.001), hepatotoxicity (28.95% vs. 17.89%, <italic>p</italic> = 0.008), oral mucositis (23.25% vs. 10.53%, <italic>p</italic> = 0.001), and grade 3/4 neutropenia (47.37% vs. 27.37%, <italic>p</italic> &lt; 0.001), while grade 1/2 diarrhea (7.46% vs. 13.68%, <italic>p</italic> = 0.037) and grade 3/4 oral mucositis (0 vs. 6.32%, <italic>p</italic> &lt; 0.001) were much more common in the FAV group. The rate of overall survival at 5 years was 96.8% in the FPV group and 97.3% in the FAV group (<italic>p</italic> = 0.760), whereas the 5-year disease-free survival rates were 95.9% and 93.9% (<italic>p</italic> = 0.754), respectively.</p></sec><sec><title>Conclusion</title><p>The FPV and FAV regimens with pulsed intravenous 5-FU yielded comparable CR rates and tolerability in patients with GTN with FIGO scores of &gt;5. Further randomized controlled trials are warranted to validate their efficacy.</p></sec>