AUTHOR=Maya Naranjo Maria Isabel , Vallejo López Sebastián , Mesa Mesa Sara , Ortiz Pérez Mónica , López Posada Mariana , Gaviria Bravo Martha Lía , González Alviar María Elena 

TITLE=Intravitreal methotrexate in type B lymphoblastic leukemia—Case Report

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1237204

DOI=10.3389/fonc.2023.1237204

ISSN=2234-943X

ABSTRACT=<p>Leukemia is a common neoplasia that, in its progress, can have ocular involvement due to direct infiltration or secondary to hematological alterations typical of the disease. These findings are consistent with an involvement of the central nervous system and are thus related to the prognosis. Despite the existing systemic therapies, there needs to be more literature that shows the treatment in the ocular involvement of this disease. A case report of a child with ocular involvement due to treatment-refractory acute lymphoblastic leukemia, successfully managed with intravitreal methotrexate, is presented.</p>