AUTHOR=Yan Jinbowen , Xu Fangzhi , Zhou Dan , Zhang Shuo , Zhang Bo , Meng Qingwei , Lv Qiubo 

TITLE=Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1231460

DOI=10.3389/fonc.2023.1231460

ISSN=2234-943X

ABSTRACT=<p>Metabolic reprogramming is a phenomenon in which cancer cells alter their metabolic pathways to support their uncontrolled growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle. These changes lead to the creation of metabolic intermediates that can provide precursors for the biosynthesis of cellular components and help maintain cellular energy homeostasis. This article reviews the research progress of the metabolic reprogramming mechanism of platinumbased chemotherapy resistance caused by three major nutrients in ovarian cancer.</p>