AUTHOR=Mix Lucas , Knoll Manuel , Häring Max-Felix , Bethge Wolfgang Andreas , Schröder Jan C. , Forchhammer Stephan , Krumm Patrick , Schürch Christian M. , Schaller Martin , Lengerke Claudia 

TITLE=Case Report: Paraneoplastic psoriasis in thymic carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1218517

DOI=10.3389/fonc.2023.1218517

ISSN=2234-943X

ABSTRACT=<p>Thymic carcinomas are exceedingly rare and very aggressive malignancies of the anterior mediastinum. While thymomas exhibit a high association with paraneoplastic syndromes, these phenomena are a rarity in thymic carcinomas. In general, acanthotic syndromes such as acroceratosis neoplastica and acanthosis nigricans maligna are commonly observed as paraneoplastic phenomena in patients with carcinomas. In contrast, psoriasis vulgaris, another acanthotic disease, rarely occurs as a paraneoplasia. We report the case of a 36-year-old patient with progressive thymic carcinoma (undifferentiated carcinoma, T3N2M1a) and paraneoplastic psoriasis occurring ten months before the initial diagnosis of the carcinoma. Over the course of the disease, new psoriatic flares heralded relapse or progression of the carcinoma. To our knowledge, this is the first reported case of paraneoplastic psoriasis in thymic carcinoma.</p>