AUTHOR=Izzo Paolo , Izzo Luciano , Lai Silvia , D’Onghia Giuliano , Giancontieri Paola , Gabriele Raimondo , Polistena Andrea , Sibio Simone , Costanzo Maria Ludovica , De Intinis Claudia , Izzo Sara TITLE=Nodular cutaneous metastasis of the leg in advanced urothelial bladder carcinoma: a case report and systematic literature review JOURNAL=Frontiers in Oncology VOLUME=13 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1216725 DOI=10.3389/fonc.2023.1216725 ISSN=2234-943X ABSTRACT=

Cutaneous metastases from urothelial carcinoma (UC) are very rare and indicate advanced disease with a poor prognosis. A 63-year-old female patient with a history of urothelial bladder carcinoma, treated 2 months prior with radical cystectomy and adjuvant gemcitabine and cisplatin (GC) therapy, presented a skin lesion localized in the lower third of the right leg. Punch biopsy revealed carcinomatous metastasis whose urothelial origin was confirmed by immunohistochemical analysis. 18-FDG PET-CT showed the spread of metastases to the lung and left ischium. Our review focuses on the time between surgery and skin metastasis, localization, and prognosis after metastasis diagnosis. In many cases, skin metastases occur within one year of initial UC surgery and in most cases occur on the abdominal wall. Local wide excision of metastasis should be considered in selected cases; however, chemotherapy remains the main treatment.