AUTHOR=Masucci Chiara , Passucci Mauro , Scalzulli Emilia , Carmosino Ida , Capriata Marcello , Costa Alessandro , Ielo Claudia , Martelli Maurizio , Breccia Massimo 

TITLE=Case Report: Avelumab and ruxolitinib to manage polycythemia vera and secondary metastatic Merkel cell carcinoma: a possible successful combination

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1212638

DOI=10.3389/fonc.2023.1212638

ISSN=2234-943X

ABSTRACT=<p>We describe a case of second primary malignancy in a 65-year-old patient affected by polycythemia vera treated with the JAK 1/2 inhibitor ruxolitinib. The latter is recognized as a risk factor for the onset of non-melanoma skin cancers in many retrospective and perspective studies, but the concomitant use of ruxolitinib with new immunotherapies is very rarely reported, and the safety of this association is still not clear. In our case, ruxolitinib combined with the anti-PD-L1 avelumab demonstrated both safety and efficacy for hematological disease control and underlying carcinoma remission.</p>