AUTHOR=Li Tianjie , Qian Xinye , Liu Jinyang , Xue Feng , Luo Jing , Yao Guanqun , Yan Jun , Liu Xiaodong , Xiao Bo , Li Jianxing 

TITLE=Radiotherapy plus immune checkpoint inhibitor in prostate cancer

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1210673

DOI=10.3389/fonc.2023.1210673

ISSN=2234-943X

ABSTRACT=<p>The immune checkpoint inhibitor (ICI) is a promising strategy for treating cancer. However, the efficiency of ICI monotherapy is limited, which could be mainly attributed to the tumor microenvironment of the “cold” tumor. Prostate cancer, a type of “cold” cancer, is the most common cancer affecting men’s health. Radiotherapy is regarded as one of the most effective prostate cancer treatments. In the era of immune therapy, the enhanced antigen presentation and immune cell infiltration caused by radiotherapy might boost the therapeutic efficacy of ICI. Here, the rationale of radiotherapy combined with ICI was reviewed. Also, the scheme of radiotherapy combined with immune checkpoint blockades was suggested as a potential option to improve the outcome of patients with prostate cancer.</p>