AUTHOR=Vinokurov Michael A. , Mironov Konstantin O. , Domonova Elvira A. , Romanyuk Tatiana N. , Popova Anna A. , Akimkin Vasiliy G. 

TITLE=The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1207935

DOI=10.3389/fonc.2023.1207935

ISSN=2234-943X

ABSTRACT=Introduction. Cervical cancer (CC) is a prevalent malignancy-affecting woman worldwide. The primary causative factor of CC is the high-risk oncogenic human papillomavirus (HR-HPV). However, it is noteworthy that not all women infected with HR-HPV develop cancer, indicating the potential involvement of genetic predisposition in the development of CC. The aim of this study is to identify genetic risks and their distribution in groups of women with different epidemiological features of HR-HPV.A comparison was conducted among four groups of women, comprising 218 HPV-negative women, 120 HPV-positive women, 191 women diagnosed with Cervical Intraepithelial Neoplasia (CIN) grade 2 or 3, and 124 women diagnosed with CC. The analysis focused on four single nucleotide polymorphisms (SNPs): rs55986091 in HLA-DQB1, rs138446575 in TTC34, rs1048943 in CYP1A1, and rs2910164 in miRNA-146a.The rs55986091-A allele exhibited a protective effect within the "CC" group when compared to the "HPV-Negative" group (OR = 0.4, 95% CI= 0.25-0.65) using a log-additive model. Additionally, similar protective effects were observed in the "CIN 2/3" group compared to the "HPV-Negative" group (OR = 0.47, 95% CI = 0.28-0.79).The data obtained emphasize the importance of developing PCR-based diagnostic kits for the identification of SNP alleles, particularly for rs55986091, among HR-HPVpositive women within the Russian population.