AUTHOR=Yang Jing , Chen Xiaowen , Li Xiaofang , Liu Wenci , Liao Sihai , Wang Yuzhou , Zuo Yufang 

TITLE=Case Report: Clinical application of immunotherapy-based combination regimen in primary osteosarcoma of the uterus

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1198765

DOI=10.3389/fonc.2023.1198765

ISSN=2234-943X

ABSTRACT=<p>Primary osteosarcoma of the uterus is an extremely rare pure heterologous sarcoma of the uterus. The relevant available information is limited to case reports. To date, only 31 cases of this type of cancer have been reported. Here, we report the first clinical experience with the administration of an immunotherapy-based combination regimen for multiple metastatic primary osteosarcomas of the uterus. The patient had undergone multiple treatments prior to this regimen, but her condition continued to progress. However, after 3 cycles of immunotherapy combined with targeted therapy and chemotherapy, a review showed that the disease was stable and even in partial remission. The patient has a good quality of life, and long-term survival is expected.</p>