AUTHOR=Xie Shuqi , Wang Mengchao , Zeng Chuanxiu , Ou Yan , Zhao Lu , Wang Dong , Chen Liwei , Kong Fanming , Yi Dan 

TITLE=Research progress of targeted therapy combined with immunotherapy for hepatocellular carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1197698

DOI=10.3389/fonc.2023.1197698

ISSN=2234-943X

ABSTRACT=<p>Hepatocellular carcinoma is a common gastrointestinal malignancy with a high mortality rate and limited treatment options. Molecularly targeted drugs combined with immune checkpoint inhibitors have shown unique advantages over single-agent applications, significantly prolonging patient survival. This paper reviews the research progress of molecular-targeted drugs combined with immune checkpoint inhibitors in the treatment of hepatocellular carcinoma and discusses the effectiveness and safety of the combination of the two drugs to provide a reference for the further application of molecular-targeted drugs combined with immune checkpoint inhibitors in clinical practice.</p>