AUTHOR=Bhavsar Swapnil Parashram 

TITLE=Metastasis in neuroblastoma: the MYCN question

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1196861

DOI=10.3389/fonc.2023.1196861

ISSN=2234-943X

ABSTRACT=<p>Oncogenic drivers like <italic>MYCN</italic> in neuroblastoma subsets continues to present a significant challenge owing to its strong correlation with high-risk metastatic disease and poor prognosis. However, only a limited number of MYCN-regulatory proteins associated with tumor initiation and progression have been elucidated. In this minireview, I summarize the recent progress in understanding the functional role of <italic>MYCN</italic> and its regulatory partners in neuroblastoma metastasis.</p>