AUTHOR=Wei Cui 

TITLE=The multifaceted roles of matrix metalloproteinases in lung cancer

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1195426

DOI=10.3389/fonc.2023.1195426

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Though the matrix metalloproteinases (MMPs) are widely investigated in lung cancer (LC), however, almost no review systematically clarify their multi-faced roles in LC.</p></sec><sec><title>Methods</title><p>We investigated the expression of MMPs and their effects on survival of patients with LC, the resistance mechanisms of MMPs in anti-tumor therapy, the regulatory networks of MMPs involved, the function of MMPs inducing CSCLs, MMPs-related tumor immunity, and effects of MMP polymorphisms on risk of LC.</p></sec><sec><title>Results</title><p>High expression of MMPs was mainly related to poor survival, high clinical stages and cancer metastasis. Role of MMPs in LC are multi-faced. MMPs are involved in drug resistance, induced CSCLs, participated in tumor immunity. Besides, MMPs polymorphisms may increase risk of LC.</p></sec><sec><title>Conclusions</title><p>MMPs might be promising targets to restore the anti-tumor immune response and enhance the killing function of nature immune cells in LC.</p></sec>