AUTHOR=Zhang Jing , Bai Jian , Gong Chen , Wang Jianhua , Cheng Yi , Zhao Jing , Xiong Huihua 

TITLE=Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1184626

DOI=10.3389/fonc.2023.1184626

ISSN=2234-943X

ABSTRACT=<p>Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells proliferate more than normal cells and require more serine for proliferation. The cancer-related genes that are involved in serine metabolism also show changes corresponding to metabolic alterations. Here, we reviewed the serine-associated one-carbon metabolism and its potential as a target for anti-tumour therapeutic strategies.</p>