AUTHOR=Burg Simon , Smeets Ralf , Gosau Martin , Failing Katja , Grust Audrey Laure Céline 

TITLE=Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1177237

DOI=10.3389/fonc.2023.1177237

ISSN=2234-943X

ABSTRACT=<p>We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (TKTL1) in circulating macrophage-like cells from peripheral blood samples to identify asymptomatic individuals with a high risk for malignancy. The elevated blood test values initiated an <sup>18</sup>F-FDG PET/CT visualization for further clarification. In this case, imaging indicated a lung carcinoma in the right upper lobe. A biopsy confirmed the presence of a lung carcinoma, which was removed surgically. Histologic examination revealed a typical I A2 carcinoid, which was completely removed, making further therapy obsolete.</p>