AUTHOR=Xiao Andrew , Shahmarvand Nahid , Nagy Alexandra , Kumar Jyoti , Van Ziffle Jessica , Devine Patrick , Huang Franklin , Lezama Lhara , Li Peng , Ohgami Robert S. 

TITLE=TFG::ALK fusion in ALK positive large B-cell lymphoma: a case report and review of literature

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1174606

DOI=10.3389/fonc.2023.1174606

ISSN=2234-943X

ABSTRACT=<p>Anaplastic lymphoma kinase (ALK) positive large B-cell lymphoma (ALK+ LBCL) is an aggressive and rare subtype of B-cell lymphoma. Patients typically present with advanced clinical stage disease and do not respond to conventional chemotherapy; the median overall survival is 1.8 years. The genetic landscape of this entity remains poorly understood. Here we report a unique case of ALK+ LBCL harbouring a rare <italic>TFG::ALK</italic> fusion. Targeted next-generation sequencing showed no significant single nucleotide variants, insertions/deletions, or other structural variants beyond the <italic>TFG::ALK</italic> fusion; deep deletions of <italic>FOXO1</italic>, <italic>PRKCA</italic>, and the <italic>MYB</italic> locus were also detected. Our case report draws attention to this rare disease, highlights a need for larger genetic profiling studies, and focuses on the pathogenesis and potential therapeutic targets of this aggressive disease. To our knowledge, this is the first report of a <italic>TFG::ALK</italic> fusion in ALK+ LBCL.</p>