AUTHOR=Asif Ali Muhammad , Khan Noohela , Kaleem Nabeeha , Ahmad Waqas , Alharethi Salem Hussain , Alharbi Bandar , Alhassan Hassan H. , Al-Enazi Maher M. , Razis Ahmad Faizal Abdull , Modu Babagana , Calina Daniela , Sharifi-Rad Javad TITLE=Anticancer properties of sulforaphane: current insights at the molecular level JOURNAL=Frontiers in Oncology VOLUME=13 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1168321 DOI=10.3389/fonc.2023.1168321 ISSN=2234-943X ABSTRACT=

Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.