AUTHOR=Zeng Zeng , Chen Cong-Xian 

TITLE=Metabonomic analysis of tumor microenvironments: a mini-review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1164266

DOI=10.3389/fonc.2023.1164266

ISSN=2234-943X

ABSTRACT=Metabonomic analysis is the vital part of studying cancer progression. Metabonomic crosstalk such as nutrient availability, transformation in physicochemical way and intercellular interactions can affect tumor metabolism. Many original studies have demonstrated that metabolomic have importance in some aspects of tumor metabolism. In this mini-review, we sum up the definition of metabolomics and how metabolomics can help change tumor microenvironment especially on three metabonomic tumors’ pathways. Just like non-invasive biofluids are identified early biomarkers on the development of tumor, metabolomics can also predict the difference of tumor drugs response, drug resistance and efficacy. We conclude the importance of metabolomics in tumor metabolic and how it can affect oncology drugs in cancer therapy.