AUTHOR=Maslov Diana V. , Sember Quinne , Cham Jason , Bhangoo Munveer 

TITLE=A review of treatments targeting DNA-repair gene defects in metastatic castration resistant prostate cancer

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1150777

DOI=10.3389/fonc.2023.1150777

ISSN=2234-943X

ABSTRACT=<p>Prostate cancer is the most common cancer in men. About 6% of those diagnosed will develop metastatic disease. Unfortunately, metastatic prostate cancer is fatal. Prostate cancer can be castration sensitive or castration resistant. Many treatments have been shown to improve progression free survival and overall survival in metastatic castration resistant prostate cancer (mCRPC). In recent years, studies have been exploring targeting mutations in the DNA Damage Repair (DDR) response that may amplify oncogenes. In this paper, we aim to discuss DDR, new approved targeted therapies, and the most recent clinical trials in the setting of metastatic CRPC.</p>