AUTHOR=Rahmati Atefe , Mafi Alireza , Soleymani Firooze , Babaei Aghdam Zahra , Masihipour Niloufar , Ghezelbash Behrooz , Asemi Reza , Aschner Michael , Vakili Omid , Homayoonfal Mina , Asemi Zatollah , Sharifi Mehran , Azadi Abbas , Mirzaei Hamed , Aghadavod Esmat 

TITLE=Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1149187

DOI=10.3389/fonc.2023.1149187

ISSN=2234-943X

ABSTRACT=<p>Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) with a unique loop structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been identified exhibiting either up-regulation or down-regulation in AML patients compared with healthy controls. Recent studies have reported that circRNAs regulate leukemia cell proliferation, stemness, and apoptosis, both positively and negatively. Additionally, circRNAs could be promising biomarkers and therapeutic targets in AML. In this study, we present a comprehensive review of the regulatory roles and potentials of a number of dysregulated circRNAs in AML.</p>