AUTHOR=Zhang Long , Liao Weiqi , Chen Shimin , Chen Yukun , Cheng Pengrui , Lu Xinjun , Ma Yi TITLE=Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment JOURNAL=Frontiers in Oncology VOLUME=13 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1146477 DOI=10.3389/fonc.2023.1146477 ISSN=2234-943X ABSTRACT=
Three-dimensional cell culture technology (3DCC) sits between two-dimensional cell culture (2DCC) and animal models and is widely used in oncology research. Compared to 2DCC, 3DCC allows cells to grow in a three-dimensional space, better simulating the