AUTHOR=Lindner Andrea Katharina , Pichler Martin , Maier Sarah , Ulmer Hanno , Gorreri Thomas , Luger Anna Katharina , Barth Dominik A. , Seeber Andreas , Kocher Florian , Pichler Renate 

TITLE=Optimization of postoperative surveillance protocols in upper tract urothelial cancer: A retrospective cohort study

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1143030

DOI=10.3389/fonc.2023.1143030

ISSN=2234-943X

ABSTRACT=<p>Upper tract urothelial carcinoma (UTUC) is an aggressive disease that is managed by radical or organ-sparing surgery. High recurrence rates require early detection and strict follow-up (FU) protocols. Recommendations are assigned to a low level of evidence. Our aim was to identify time-to-tumor recurrence, analyze the temporal relation to recommended FU regimens, and provide a critical proposal for further surveillance. This retrospective study included 54 patients receiving radical nephroureterectomy (RNU) in high-risk UTUC and 14 patients assigned to kidney-sparing surgery (KSS) with low-risk disease. FU surveillance protocols consisted of close intervals irrespective of the received type of surgery. In total, 68 patients were included with a median FU of 23 months. Mean overall survival (OS) was significantly shorter in RNU compared to KSS (<italic>P</italic> = .027). Recurrence in the bladder and/or upper urinary tract (UUT) was 57.1% in KSS and 38.9% after RNU (<italic>P</italic> = .241). Mean recurrence-free survival (RFS) was significantly shorter in RNU patients compared to KSS (22.4 <italic>vs.</italic> 47.9 months, <italic>P = .</italic>013), and 76.2% of the recurrences in the RNU group occurred in the first postoperative year. UUT recurrence was diagnosed after a median of 3.0 (RNU) and 25.0 (KSS) months. There was a frequent onset of metastases in the RNU group, with 85.7% in the first year compared to the KSS group with 50%. Multivariable regression analysis showed that the tumor stage was the parameter independently related to OS (<italic>P = .</italic>002), RFS (<italic>P = .</italic>008), and metastasis-free survival (MFS, <italic>P</italic> = .002). In conclusion, surveillance of UTUC should be adapted to real-time occurrence patterns. Strict imaging protocols are recommended in the first two years irrespective of the method of surgery. As recurrence is equally distributed over the years after KSS, cystoscopy should be offered regularly for five years and diagnostic URS for three years. After RNU, cystoscopies should be decreased to yearly intervals after year three. Contralateral UUT should also be examined after RNU.</p>