AUTHOR=Shi Hongyang , Zhang Yonghong , Wang Yu , Fang Ping , Liu Yun 

TITLE=Genetic polymorphisms in CYP4F2 may be associated with lung cancer risk among females and no-smoking Chinese population

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1114218

DOI=10.3389/fonc.2023.1114218

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Our study aimed to explore the potential association of <italic>CYP4F2</italic> gene polymorphisms with lung cancer (LC) risk.</p></sec><sec><title>Methods</title><p>The five variants in <italic>CYP4F2</italic> were genotyped using Agena MassARRAY in 507 cases and 505 controls. Genetic models and haplotypes based on logistic regression analysis were used to evaluate the potential association between <italic>CYP4F2</italic> polymorphisms and LC susceptibility.</p></sec><sec><title>Results</title><p>This study observed that rs12459936 was linked to an increased risk of LC in no-smoking participants (allele: OR = 1.38, <italic>p</italic> = 0.035; homozygote: OR = 2.00, <italic>p</italic> = 0.035; additive: OR = 1.40, <italic>p</italic> = 0.034) and females (allele: OR = 1.64, <italic>p</italic> = 0.002; homozygote: OR = 2.57, <italic>p</italic> = 0.006; heterozygous: OR = 2.56, <italic>p</italic> = 0.001; dominant: OR = 2.56, <italic>p &lt;</italic> 0.002; additive: OR = 1.67, <italic>p</italic> = 0.002). Adversely, there was a significantly decreased LC risk for rs3093110 in no-smoking participants (heterozygous: OR = 0.56, <italic>p</italic> = 0.027; dominant: OR = 0.58, <italic>p</italic> = 0.035), rs3093193 (allele: OR = 0.66, <italic>p</italic> = 0.016; homozygote: OR = 0.33, <italic>p</italic> = 0.011; recessive: OR = 0.38, <italic>p</italic> = 0.021; additive: OR = 0.64, <italic>p</italic> = 0.014), rs3093144 (recessive: OR = 0.20, <italic>p</italic> = 0.045), and rs3093110 (allele: OR = 0.54, <italic>p</italic> = 0.010; heterozygous: OR = 0.50, <italic>p</italic> = 0.014; dominant: OR = 0.49, <italic>p</italic> = 0.010; additive: OR = 0.54, <italic>p</italic> = 0.011) in females.</p></sec><sec><title>Conclusions</title><p>The study demonstrated that <italic>CYP4F2</italic> variants were associated with LC susceptibility, with evidence suggesting that this connection may be affected by gender and smoking status.</p></sec>