AUTHOR=Tadesse Fikremariam Abiye , Leminie Abebaye Aragaw 

TITLE=Effects of Adriamycin-Cytoxan chemotherapy on hematological and electrolyte parameters among breast cancer patients

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1103013

DOI=10.3389/fonc.2023.1103013

ISSN=2234-943X

ABSTRACT=Background: Adriamycin-Cytoxan (AC) is a common chemotherapy treatment for breast cancer (BC) patients. Its electrolyte and hematological adverse effects have not been addressed adequately. 
Objective: This study aimed to assess the effect of AC on hematological and electrolyte parameters among BC patients. 
Methods: A hospital-based comparative cross-sectional study design was conducted from March to November 2022. Randomly selected AC-treated (n=100) and untreated (n=100) patients were included. Structured questionnaire and medical records were used to collect sociodemographic data. Anthropometric parameters, hematological indices, and serum electrolytes were measured. Cobas Integra 400+and SYSMEX-XT-4000i were used to analyze serum electrolytes and hematological indices respectively. The data were analyzed using SPSS version 25. Independent t-test and chi-square test were used. P-value < 0.05 was considered statistically significant.
Results: AC-treated patients’ mean TWBC, NE, LY, RBC, Hgb, HCT, and Na+ values were significantly reduced (p<0.05) than patients with no treatment. However, mean EO, PLT counts, RDW, K+, and PCT values were significantly increased (p<0.05). Moreover, the mean EO count was significantly increased (p<0.05) for AC-treated advanced cancer-stage patients. 
Conclusion: The majority of blood cells and serum sodium were affected by AC treatment. Incorporating these parameters in the routine analysis and further studies on the detailed mechanism of action of this drug is required.