AUTHOR=Shalata Walid , Steckbeck Rachel , Polishchuk Ilya , Cohen Ahron Yehonatan , Rouvinov Keren , Tokar Margarita , Abu Jama Ashraf , Abu Saleh Omar , Sheva Kim , Yakobson Alexander 

TITLE=Safety and rapid response of dabrafenib and trametinib therapy during hyperbilirubinemia in metastatic melanoma

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1102330

DOI=10.3389/fonc.2023.1102330

ISSN=2234-943X

ABSTRACT=<p>This case report describes the occurrence of hyperbilirubinemia as a complication of metastatic melanoma. A 72-year-old male patient was diagnosed with BRAF V600E-mutated melanoma with metastases in the liver, lymph nodes, lungs, pancreas, and stomach. Due to a lack of clinical data and specific guidelines for the treatment of mutated metastatic melanoma patients with hyperbilirubinemia, a conference of specialists debated between initiating treatment or providing supportive care. Ultimately, the patient was started on the combination therapy of dabrafenib and trametinib. This treatment resulted in a significant therapeutic response <italic>via</italic> normalization of bilirubin levels and an impressive radiological response of metastases just one month post-treatment initiation.</p>