AUTHOR=Vetrone Luigia , Cuzzani Giulia , Mei Riccardo , Zanoni Lucia , Bertaccini Alessandro , Bianchi Lorenzo , Castellucci Paolo , Gaudiano Caterina , Cappelli Alberta , Giunchi Francesca , Fanti Stefano 

TITLE=Case report: PSMA PET/CT addresses the correct diagnosis in a patient with metastatic prostate cancer despite negative core biopsies and mpMRI. A diagnostic challenge

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1101221

DOI=10.3389/fonc.2023.1101221

ISSN=2234-943X

ABSTRACT=<p>This is a case of [<sup>68</sup> Ga]Ga-Prostate-specific membrane antigen (PSMA)-11 PET/CT in a 73-years old patient presenting high Prostate Specific Antigen (PSA) levels despite both multi-parametric magnetic resonance imaging (mpMRI) and 12-core saturation biopsy negative for prostate cancer (Pca). This is a highly interesting case because, despite the advanced metastatic spread at initial presentation as showed by [<sup>68</sup>Ga]Ga-PSMA-PET/CT, the primary Pca was detected by none of the diagnostic techniques (12 random sample biopsy, mpMRI, PSMA PET/CT). However, [<sup>68</sup>Ga]Ga-PSMA-PET/CT showed a suspicious axillary lesion suitable for biopsy, which finally resulted as Pca metastasis. This case report is therefore a brilliant example of how [<sup>68</sup>Ga]Ga-PSMA-PET/CT optimized patient’s management.</p>