AUTHOR=Li Peishun , Bai Yunling , Yuan Qianqian , Man Qirong , Xing Chao , Ren Yanchen , Zhang Kaixian 

TITLE=Efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1084904

DOI=10.3389/fonc.2023.1084904

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p>To evaluate the efficacy safety of computed tomography (CT)-guided <sup>125</sup>I seed implantation by coplanar template for vertebral metastases after failure of external beam radiation therapy (EBRT).</p></sec><sec><title>Material and methods</title><p>Retrospective analysis of the clinical outcomes of 58 patients with vertebral metastases after failure of EBRT, who underwent <sup>125</sup>I seed implantation as a salvage treatment with a CT-guided coplanar template-assisted technique from January 2015 to January 2017.</p></sec><sec><title>Results</title><p>The mean post-operative NRS score decreased significantly at T<sub>4w</sub> (3.5 ± 0.9, p&lt;0.01), T<sub>8w</sub> (2.1 ± 0.9, p&lt;0.01), T<sub>12w</sub> (1.5 ± 0.7, p&lt; 0.01) and T<sub>6m</sub> (1.2 ± 0.6, p&lt; 0.01) respectively. The local control rates after 3, 6, 9 and 12 months were 100% (58/58), 93.1% (54/58), 87.9% (51/58), and 81% (47/58), respectively. The median overall survival time was 18.52months (95% CI, 16.24-20.8), and 1- and 2-year survival rates were 81% (47/58) and 34.5% (20/58), respectively. By performing a paired t-test analysis, there was no significant difference in D90, V90, D100, V100, V150, V200, GTV volume, CI, EI and HI between preoperative and postoperative (p&gt;0.05).</p></sec><sec><title>Conclusions</title><p><sup>125</sup>I seed implantation can be used as a salvage treatment for patients with vertebral metastases after failure of EBRT.</p></sec>