AUTHOR=Zhou Ruizhi , Liang Tianqi , Li Tianwen , Huang Junbin , Chen Chun TITLE=Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemia JOURNAL=Frontiers in Oncology VOLUME=13 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1070069 DOI=10.3389/fonc.2023.1070069 ISSN=2234-943X ABSTRACT=
L-asparaginase, which hydrolyzes asparagine into aspartic acid and ammonia, is frequently used to treat acute lymphoblastic leukaemia in children. When combined with other chemotherapy drugs, the event-free survival rate is 90%. Due to immunogenicity and drug resistance, however, not all patients benefit from it, restricting the use of L-asparaginase therapy in other haematological cancers. To solve the problem of immunogenicity, several L-ASNase variants have emerged, such as