AUTHOR=Nguyen Quynh-Anh , Chou Wan-Hsuan , Hsieh Mao-Chih , Chang Che-Mai , Luo Wei-Tzu , Tai Yu-Ting , Chang Wei-Chiao 

TITLE=Genetic alterations in peritoneal metastatic tumors predicted the outcomes for hyperthermic intraperitoneal chemotherapy

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1054406

DOI=10.3389/fonc.2023.1054406

ISSN=2234-943X

ABSTRACT=<sec><title>Introduction</title><p>Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are considered for patients with peritoneal metastasis (PM). However, patients selection that relies on conventional prognostic factors is not yet optimal. In this study, we performed whole exome sequencing (WES) to establish tumor molecular characteristics and expect to identify prognosis profiles for PM management. </p></sec><sec><title>Methods</title><p>In this study, blood and tumor samples were collected from patients with PM before HIPEC. Tumor molecular signatures were determined using WES. Patient cohort was divided into responders and non-responders according to 12-month progression-free survival (PFS). Genomic characteristics between the two cohorts were compared to study potential targets. </p></sec><sec><title>Results</title><p>In total, 15 patients with PM were enrolled in this study. Driver genes and enriched pathways were identified from WES results. AGAP5 mutation was found in all responders. This mutation was significantly associated with better OS (p = 0.00652). </p></sec><sec><title>Conclusions</title><p>We identified prognostic markers that might be useful to facilitate decision-making before CRS/HIPEC.</p></sec>