AUTHOR=Inno Alessandro , Lattuada Emanuela , Foti Giovanni , Gori Stefania 

TITLE=Chemo-immunotherapy for metastatic non-squamous NSCLC in a patient with HIV infection: A case report

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1053497

DOI=10.3389/fonc.2023.1053497

ISSN=2234-943X

ABSTRACT=<p>Activity and safety data of chemo-immunotherapy for patients with metastatic NSCLC and known HIV infection are still limited, since HIV-positive patients were generally excluded from clinical trials. Here we report the case of a metastatic NSCLC patient with HIV infection and undetectable viral load treated with first-line chemo-immunotherapy (pembrolizumab, carboplatin and pemetrexed), achieving a meaningful and durable objective response, with no treatment-related adverse events and no HIV-related complications. This report suggests that NSCLC patients with virologically controlled HIV infection can be safely treated with chemo-immunotherapy and should not be excluded from this treatment based on their viral infection only.</p>