AUTHOR=Wang Xuedong , Li Lei , Wang Linjie , Chen Min 

TITLE=The expression of Ki-67 and Glypican -3 in hepatocellular carcinoma was evaluated by comparing DWI and 18F-FDG PET/CT

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1026245

DOI=10.3389/fonc.2023.1026245

ISSN=2234-943X

ABSTRACT=<sec><title>Objective</title><p>The value of DWI and <sup>18</sup>F-FDG PET/CT in evaluating the expression of Ki-67 and GPC-3 in HCC was compared.</p></sec><sec><title>Materials and methods</title><p>Ninety-four patients with primary HCC confirmed by pathology were retrospectively divided into high- and low-Ki-67-expression groups and positive- and negative- GPC-3 groups. The ADC and SUVmax values of the lesions in both groups were measured. ROC curves were used to evaluate the identification efficiency of parameters with significant differences for each group of lesions, and AUCwas calculated. The combined ADC and SUVmax values were analyzed by binary logistic regression. The Delong test was used to compare the AUC values of the combined and single parameters. Pearson (in line with normal distribution) or Spearman (in line with abnormal distribution) correlation analysis was used to analyze the correlation.</p></sec><sec><title>Results</title><p>The ADC value of the high-Ki-67-expression group was lower than that of the low-Ki-67-expression group (<italic>P</italic>&lt;0.05), and the SUVmax value of the high-expression group was higher than that of the low-expression group (<italic>P</italic>&lt;0.05). The ADC value of the positive-GPC-3 group was lower than that of the negative group (<italic>P</italic>&lt;0.0.tive group (<italic>P</italic>&lt;0.05). The combined ADC and SUVmax values in the GPC-3 group were better than those of a single parameter (<italic>P</italic>&lt;0.05). There was a strong negative correlation between the SUVmax value and ADC value in the Ki-67 group (R=-0.578, <italic>P</italic>&lt;0.001) and a weak negative correlation between the SUVmax value and ADC value in the GPC-3 group (R=-0.279, <italic>P</italic>=0.006). The SUVmax value was strongly positively correlated with the Ki-67 expression index (R=0.733, <italic>P</italic>&lt;0.001), while the ADC value was strongly negatively correlated with the Ki-67 expression index (R=-0.687, <italic>P</italic>&lt;0.001).</p></sec><sec><title>Conclusion</title><p>DWI and <sup>18</sup>F-FDG PET/CT can be used to evaluate the expression of Ki-67 and GPC-3 in HCC, and there is a certain correlation between the ADC value and SUVmax. Combined DWI and <sup>18</sup>F-FDG PET/CT is superior to a single technique in evaluating the expression of GPC-3 in HCC patients. However, the combined model did not benefit the Ki-67 group.</p></sec>