AUTHOR=Zang Bolun , Ding Luyue , Liu Linlin , Arun Kumar Senthil , Liu Wei , Zhou Chongchen , Duan Yongtao 

TITLE=The immunotherapy advancement targeting malignant blastomas in early childhood

JOURNAL=Frontiers in Oncology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1015115

DOI=10.3389/fonc.2023.1015115

ISSN=2234-943X

ABSTRACT=<p>Malignant blastomas develop relentlessly in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in functional body organs. Surprisingly, neither of these preferred treatment types (surgery, radiotherapy, and chemotherapy) showed promise or were effective in treating malignant blastomas among child patients. N ew, innovative immunotherapeutic procedures including monoclonal antibodies and chimeric-antigen based receptor (CAR) cell therapy, coupled with the clinical study of reliable therapeutic targets and immune regulatory pathways targeting malignant blastomas, have attracted the attention of clinicians recently.</p>