AUTHOR=Ledinek Živa , Sobočan Monika , Sisinger Damjan , Hojnik Marko , Büdefeld Tomaž , Potočnik Uroš , Knez Jure 

TITLE=The association of Wnt-signalling and EMT markers with clinical characteristics in women with endometrial cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1013463

DOI=10.3389/fonc.2023.1013463

ISSN=2234-943X

ABSTRACT=Endometrial cancer is the most common gynaecologic malignancy in the developed world. Risk stratification and treatment approaches are changing due to better understanding of tumour biology. Upregulated Wnt signalling plays an important role in cancer initiation and progression with promising potential for development of specific Wnt inhibitor therapy. One of the ways in which Wnt signalling contributes to progression of cancer, is by activating epithelial-to-mesenchymal transition (EMT) in tumour cells, causing the expression of mesenchymal markers, and enabling tumour cells to dissociate and migrate. This study analysed the expression of Wnt signalling and EMT markers in endometrial cancer. Wnt signalling and EMT markers were significantly correlated with hormone receptors status in EC, but not with other clinico-pathological characteristics. Expression of Wnt antagonist, Dkk1 was significantly different between the ESGO-ESTRO-ESP patient risk assessment categories using integrated molecular risk assessment.