AUTHOR=Kanikarla Marie Preeti , Sorokin Alexey V. , Bitner Lea A. , Aden Rebecca , Lam Michael , Manyam Ganiraju , Woods Melanie N. , Anderson Amanda , Capasso Anna , Fowlkes Natalie , Overman Michael J. , Menter David G. , Kopetz Scott TITLE=Autologous humanized mouse models to study combination and single-agent immunotherapy for colorectal cancer patient-derived xenografts JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.994333 DOI=10.3389/fonc.2022.994333 ISSN=2234-943X ABSTRACT=
Designing studies of immunotherapy is limited due to a lack of pre-clinical models that reliably predict effective immunotherapy responses. To address this gap, we developed humanized mouse models of colorectal cancer (CRC) incorporating patient-derived xenografts (PDX) with human peripheral blood mononuclear cells (PBMC). Humanized mice with CRC PDXs were generated