AUTHOR=Ambrosio Marco , Raffone Antonio , Alletto Andrea , Cini Chiara , Filipponi Francesco , Neola Daniele , Fabbri Matilde , Arena Alessandro , Raimondo Diego , Salucci Paolo , Guerrini Manuela , Travaglino Antonio , Paradisi Roberto , Mollo Antonio , Seracchioli Renato , Casadio Paolo 

TITLE=Is preoperative ultrasound tumor size a prognostic factor in endometrial carcinoma patients?

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.993629

DOI=10.3389/fonc.2022.993629

ISSN=2234-943X

ABSTRACT=Objective: We aimed to assess the prognostic value of preoperative ultrasound tumor size in EC through a single center, observational, retrospective, cohort study. 
Methods: Medical records and electronic clinical databases were searched for all consecutive patients with EC, preoperative ultrasound scans available to ad hoc estimate tumor size, and a follow-up of at least 2-year, at our Institution from January 2010 to June 2018. Patients were divided into two groups based on different dimensional cut-offs for the maximum tumor diameter: 2, 3 and 4 cm. Differences in overall survival (OS), disease specific survival (DSS) and progression-free survival (PFS) were assessed among the groups by using the Kaplan–Meier estimator and the log-rank test. 
Results: 108 patients were included in the study. OS, DSS and PFS did not significantly differ between the groups based on the different tumor diameter cut-offs. No significant differences were found among the groups sub-stratified by age, BMI, FIGO stage, FIGO grade, lymphovascular space invasion status, myometrial invasion, lymph nodal involvement, histotype, and adjuvant treatment. 
Conclusions: Preoperative ultrasound tumor size does not appear as a prognostic factor in EC women.