AUTHOR=Geddes Andrea E. , Ray Anita L. , Nofchissey Robert A. , Esmaeili Azadeh , Saunders Apryl , Bender Dawn E. , Khan Maaz , Aravindan Sheeja , Ahrendsen Jared T. , Li Min , Fung Kar-Ming , Jayaraman Muralidharan , Yang Jingxuan , Booth Kristina K. , Dunn Gary D. , Carter Steven N. , Morris Katherine T. TITLE=An analysis of sexual dimorphism in the tumor microenvironment of colorectal cancer JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.986103 DOI=10.3389/fonc.2022.986103 ISSN=2234-943X ABSTRACT=
Women with colorectal cancer (CRC) have survival advantages over men, yet the underlying mechanisms are unclear. T cell infiltration within the CRC tumor microenvironment (TME) correlates strongly with survival. We hypothesized that women with CRC have increased T cell infiltration and differential gene expression in the TME compared to men. Tissue microarrays comprising primary tumor, tumor infiltrated lymph nodes, and uninvolved colon were created from CRC patients. Proportions of CD4 positive (CD4+) and CD8 positive (CD8+) T cells were identified using immunohistochemistry. TME immune- and cancer-related genetic expression from primary and metastatic CRC tumor were also evaluated