AUTHOR=Bhattacharjee Rahul , Kumar Lamha , Dhasmana Archna , Mitra Tamoghni , Dey Abhijit , Malik Sumira , Kim Bonglee , Gundamaraju Rohit TITLE=Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.977933 DOI=10.3389/fonc.2022.977933 ISSN=2234-943X ABSTRACT=

Human papillomavirus (HPV) contributes to sexually transmitted infection, which is primarily associated with pre-cancerous and cancerous lesions in both men and women and is among the neglected cancerous infections in the world. At global level, two-, four-, and nine-valent pure L1 protein encompassed vaccines in targeting high-risk HPV strains using recombinant DNA technology are available. Therapeutic vaccines are produced by early and late oncoproteins that impart superior cell immunity to preventive vaccines that are under investigation. In the current review, we have not only discussed the clinical significance and importance of both preventive and therapeutic vaccines but also highlighted their dosage and mode of administration. This review is novel in its way and will pave the way for researchers to address the challenges posed by HPV-based vaccines at the present time.