AUTHOR=Liu Xuemei , Wu Xinglong , Zhu Jiaxing , Yagi Kazuyoshi , Ajioka Yoichi , Terai Shuji , Mizuno Kenichi , Li Hongping , Tuo Biguang , Di Lianjun 

TITLE=Case report: New subtype of gastric adenocarcinoma arising from an H. pylori infection-negative stomach: Foveolar epithelium and mucous neck cell-mixed type adenocarcinoma

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.970231

DOI=10.3389/fonc.2022.970231

ISSN=2234-943X

ABSTRACT=<p>The characteristics of <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection-negative gastric cancer have not been well documented because of its rarity, despite several types of <italic>H. pylori</italic> infection-negative gastric cancers being reported. In this report, we describe a case of early gastric cancer that developed without <italic>H. pylori</italic> infection with characteristic magnifying narrow-band imaging and novel histological findings. The difficulty in making an accurate diagnosis and differential diagnosis is highlighted, with the goal of providing more clinical experience for the diagnosis of <italic>H. pylori</italic> infection-negative gastric cancer.</p>