AUTHOR=Kornietskaya Anna , Evdokimova Sevindzh , Kachmazov Andrei , Fedenko Alexander. , Bolotina Larisa , Sidorov Dmitriy , Volchenko Nadezhda , Goeva Natalia , Govaleshko Anastasia , Kaprin Andrey 

TITLE=Endocrine therapy for metastatic solid pseudopapillary neoplasm of the pancreas: A case report

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.970142

DOI=10.3389/fonc.2022.970142

ISSN=2234-943X

ABSTRACT=<p>Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare tumor, associated with favorable prognosis and long-term survival in patients with advanced disease. However, limited data exist on systemic therapy for such patients. Herein, we present a case of a young woman with a history of SPN, who progressed after multiple surgical resections and chemotherapy regimens. The immunohistochemistry (IHC) showed overexpression of estrogen receptors (ER) and progesterone receptors (PR) in tumor tissue. The patient started to receive tamoxifen and showed a durable response to endocrine therapy.</p>