AUTHOR=Savan N. Anna , Saavedra Paulo Vilar , Halim Alan , Yuzbasiyan-Gurkan Vilma , Wang Ping , Yoo Byunghee , Kiupel Matti , Sempere Lorenzo , Medarova Zdravka , Moore Anna TITLE=Case report: MicroRNA-10b as a therapeutic target in feline metastatic mammary carcinoma and its implications for human clinical trials JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.959630 DOI=10.3389/fonc.2022.959630 ISSN=2234-943X ABSTRACT=
Ninety percent of deaths from cancer are caused by metastasis. miRNAs are critical players in biological processes such as proliferation, metastasis, apoptosis, and self-renewal. We and others have previously demonstrated that miRNA-10b promotes metastatic cell migration and invasion. Importantly, we also showed that miR-10b is a critical driver of metastatic cell viability and proliferation. To treat established metastases by inhibiting miR-10b, we utilized a therapeutic, termed MN-anti-miR10b, composed of anti-miR-10b antagomirs, conjugated to iron oxide nanoparticles, that serve as delivery vehicles to tumor cells