AUTHOR=Li Feiyu , Jiang Yong , Jiang Liyong , Li Qingbin , Yan Xiangyu , Huang Songhan , Chen Ji , Yuan Shuai , Fu Yingda , Liu Jun 

TITLE=Effect of lymph node resection on prognosis of resectable intrahepatic cholangiocarcinoma: A systematic review and meta-analysis

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.957792

DOI=10.3389/fonc.2022.957792

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>The purpose of this meta-analysis was to evaluate the efficacy of lymph node dissection in patients with intrahepatic cholangiocarcinoma (ICC).</p></sec><sec><title>Methods</title><p>The literature from January 2009 to December 2021 was searched to determine the comparative study of lymph node dissection and non-lymph node dissection in patients with ICC.</p></sec><sec><title>Results</title><p>Seventeen studies were included in the analysis. There were no significant differences in 1-, 3-, and 5-year overall survival (OR = 0.80, p = 0.10; OR = 0.93, p = 0.71; OR = 0.80, p = 0.21) and 1-, 3-, and 5-year disease-free survival (OR = 0.89, p = 0.73; OR = 0.92, p = 0.81; OR = 0.85, p = 0.62).</p></sec><sec><title>Conclusions</title><p>Lymph node dissection does not seem to have a positive effect on the overall survival and disease-free survival.</p></sec>