AUTHOR=Meng Tianyu , Meng Xiangxi , Xu Xiaoxia , Li Xiaofan , Yang Zhi , Li Nan 

TITLE=Role of 18FDG PET/CT metabolic parameters in predicting hematological toxicity during chemoradiotherapy for locally advanced cervical cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.956652

DOI=10.3389/fonc.2022.956652

ISSN=2234-943X

ABSTRACT=Purpose: To evaluate the value of 18FDG PET / CT metabolic parameters in predicting hematological toxicity (HT) during chemoradiotherapy (CRT) for locally advanced cervical cancer.
Methods and Materials: 41 patients with locally advanced cervical cancer (LACC) undergoing concurrent CRT were retrospectively analyzed. The correlations among age, BMI, FIGO stage, differentiation, maximum diameter of primary lesion, parametrial invasion, lymph node metastasis, Pelvic active bone marrow volume (BMACT), BMACT volume percentage (BMACT%), maximum SUV (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and HT were analyzed using hypothesis testing and logistic regression. A p value < 0.05 was considered significant unless otherwise specified.
Results: Among the 41 patients, 19 had grade 3-4 HT, and 22 had grade 0-2 HT. Only SUVmax (Z=-1.961, p=0.050) and BMACT% (χ2=7.769, p=0.020) showed statistically significant difference in univariate analysis. In logistic regression, grade 3-4 HT was not associated with SUVmax. The probability of HT occurrence in <30% BMACT% was 0.071 times less than in 30-40% BMACT% (p=0.010, OR=0.071, 95%CI=0.010-0.532), and the probability of HT occurrence in >40% BMACT% was 0.148 times less than in 30-40% BMACT% (p=0.037, OR=0.148, 95%CI=0.025-0.892).
Conclusion: Baseline 18FDG PET / CT BMACT% could help predict the severity of hematological toxicity during chemoradiotherapy for locally advanced cervical cancer.