AUTHOR=Zhu Dongze , Wang Lei , Fu Jun , Guo Zheng , Wang Zhen , Fan Hongbin 

TITLE=Comparison of customized 3D-printed prosthesis and screw-rod-cage system reconstruction following resection of periacetabular tumors

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.953266

DOI=10.3389/fonc.2022.953266

ISSN=2234-943X

ABSTRACT=Abstract
Background and Purpose: Various operative methods are used for reconstructing pelvic girdle after the resection of primary malignant periacetabular tumor have been reported. The objective of this study was to evaluate the accuracy, effectiveness and safety of customized, three dimensional-printed prosthesis (3DP) in the reconstruction of bone defects compared with conventional reconstruction using screw-rod-cage system. 
Methods: A retrospective case-control analysis of 40 patients who underwent pelvic tumor resection and reconstruction with customized, 3D-printed prosthesis (3DP) or screw-rod-cage system (SRCS) between January 2010 to December 2019 was performed. The minimum follow-up time for patients alive was 2 years. Blood loss, operation time, complications, surgical margin, local recurrence, distant metastases, status at time of latest follow-up, MSTS-93 score, Harris hip score and postoperative radiographic parameters were recorded. Moreover, overall survival, tumor-free survival, and prosthesis survival rates in both groups were compared. 
Results: Customized, 3DP reconstruction was performed in 15 patients and SRCS reconstruction was done in 25 patients. Patients treated with customized, 3DP group had significantly shorter operation time (323.7 ± 83.7 vs 393.6 ± 98.8 minutes; P=0.028) and more precise (all P<0.05) radiographic reconstruction parameters than patients in SRCS group. Fewer complications (P=0.026), better MSTS score (P=0.030) and better Harris hip score (P=0.016) were achieved in patients of 3DP group. Furthermore, survival rate of prosthesis was also significantly better in 3DP group (P=0.039). However, the blood loss, surgical margin, local recurrence, distant metastases, status at time of latest follow-up had no significant difference between two groups. 
Conclusion: Compared with the screw-rod-cage system reconstruction, the customized, 3D-printed prosthesis reconstruction is equally safe and effective, but it is more accurate and time-saving as well as associated with fewer complications.