AUTHOR=Xu Rui , Gu Qiong , Xiao Shuomeng , Zhao Ping , Ding Zhi 

TITLE=Patient-reported gastrointestinal symptoms following surgery for gastric cancer and the relative risk factors

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.951485

DOI=10.3389/fonc.2022.951485

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p>The study aims to assess the incidence of short-term patient-reported postoperative gastrointestinal symptoms (PGISs) after gastric cancer surgery and explore the relative risk factors for the symptoms.</p></sec><sec><title>Methods</title><p>Patients with radical gastrectomy were included for this retrospective and observational study. Symptoms extracted from the MD Anderson Symptom Inventory Gastrointestinal Cancer Module (MDASI-GI) were collected in postdischarge week (PDW) 1 and postoperative month (POM) 1. The distributing states of symptoms were analyzed in PDW1 and POM1. Logistic regression models were used to identify risk factors for PGISs.</p></sec><sec><title>Results</title><p>Among 356 patients with complete interviews, 156 (43.8%) patients reported abdominal distention in PDW1, which was significantly higher than patients in POM1 [103 (28.9%), <italic>p</italic> &lt; 0.001]. Pain (15.2% vs. 9.8%), dysphagia (5.6% vs. 7.0%), diarrhea (3.7% vs. 3.4%), and vomiting (2.5% vs. 2.8%) had no significant differences between PDW1 and POM1. Logistic models found that risk factors for PGISs were total gastrectomy [odds ratio (OR): 1.948; 95% CI: 1.097–3.459; <italic>p</italic> = 0.023] and disturbed sleep (OR: 3.116; 95% CI: 1.831–5.303; <italic>p</italic> &lt; 0.001) in PDW1 and female gender (OR: 1.726; 95% CI: 1.071–2.782; <italic>p</italic> = 0.025), total gastrectomy (OR: 1.729; 95% CI: 1.055–2.834; <italic>p</italic> = 0.030), and disturbed sleep (OR: 3.533; 95% CI: 1.757–7.106; <italic>p</italic> &lt; 0.001) in POM1.</p></sec><sec><title>Conclusions</title><p>The main symptom after gastric cancer surgery was abdominal distention. The relative risk factors for gastrointestinal symptoms after gastric cancer surgery were total gastrectomy and disturbed sleep. Timely symptom intervention may improve the quality of life of postgastrectomy patients.</p></sec>