AUTHOR=Zhuang Tony Zibo , Harik Lara , Force Seth , Hadadi Agreen , Bilen Mehmet Asim , Brown Jacqueline T. , Carthon Bradley C. , Goldman Jamie , Kucuk Omer , Master Viraj A. , Nazha Bassel TITLE=Durable complete response for oligometastatic renal cell carcinoma with immune checkpoint inhibition and cytoreductive nephrectomy in a Jehovah’s witness: A case report JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.949400 DOI=10.3389/fonc.2022.949400 ISSN=2234-943X ABSTRACT=

The role of cytoreductive nephrectomy in patients with metastatic renal cell carcinoma is a subject of debate. We report a durable complete response in a 62-year-old man Jehovah’s Witness with metastatic clear cell renal cell carcinoma who received two cycles of nivolumab/ipilimumab followed by radical nephrectomy and metastasectomy of known pulmonary disease site, both without a clinical need for perioperative blood transfusions. The patient continues to be without evidence of disease and without additional need for systemic therapy over a year after his radical nephrectomy. The case highlights that cytoreductive nephrectomy continues to play a role in the era of immune checkpoint inhibitors.